This cactus is notable for its role in the hybridization of many of today's hybrid Epiphyllums, though it is actually classified as a Disocactus. Slight variations in flower color can occur due to the conditions in its original native climate, as it spans a broad range from Mexico to Honduras and Guatemala. It prefers a soil mix containing 25% coarse sand, pumice, or grit for proper drainage.
For cultivation from seeds, Disocactus nelsonii requires rich yet well-draining soil, regular watering, and fertilization. It needs abundant watering during the growth period so the soil becomes thoroughly soaked, but it should dry out between waterings. In winter or when nighttime temperatures fall below 50°F (10°C), it's best kept relatively dry. It enjoys direct sunlight but can tolerate light shade. It can be grown outdoors in USDA hardiness zones 10a to 11b, from 30°F (−1.1°C) to 50°F (+10°C).
Propagation can be done through cuttings or seeds. Stem cuttings are the simplest method: cut the top off a Disocactus nelsonii stem and let the cutting callus for a week or two before placing it in a well-draining soil mix. Growing from seeds requires patience but is equally rewarding. Sow the seeds on top of the soil, pressing them down lightly, keeping the soil moist until germination, and providing a consistent temperature between 70 to 80°F (21 to 26.6°C).
Native to Mexico, Guatemala, and Honduras, this cactus doesn't suffer from significant pest or disease issues if not overwatered. It's non-toxic to humans or animals, but the spines are pointed, so handle with care.